The Got Milk company had an ad about how Milk apparently alleviates the symptoms of PMS, and it featured a picture of a hapless looking man with the caption: "When Everything I do is Wrong." They had to change it because a bunch of women complained that PMS is nothing to joke about. Probably because they were on their period or something.

 You see ladies, this is why men think you're not funny. PMS happens to every woman, and for the most part it's not that serious a medical problem. I mean, it happens every month. It's not like they made a breast cancer ad with the caption "When your own boobies turn on you."

It would be like if they made a joke about how men go bald, but then men everywhere got all pissed off and demanded they change it.